Could be a many reasons:

• You want to learn how things work under the hood. In that case Arch or Gentoo are a great learning experience.
• You want the bleeding edge versions of all your software, so you switch to something with a rolling release.
• You decide there’s another DE you like better than Cinnamon. You could switch to a distro built around said DE.
• You want the absolute best gaming performance, so you switch to CachyOS. (I don’t really expect a very noticable difference with Mint with a newer kernel and the appropriate GPU driver, though.)
• You want to reproduce your exact installation on as many computers as you like based on a single config file. You also want to easily roll back if an upgrade goes wrong. You switch to NixOS or Guix.
• Etc…

There is a Python library for everything. That’s what makes out so versatile. If performance is not an issue and it doesn’t need to run in the browser, Python is virtually always an option.

If you’re just doing basic CRUD stuff that doesn’t need to scale, sure. Even then IMO it’s a good idea to understand the underlying database queries.

Learn SQL so your website can use a database like PostgreSQL.