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Joined 2 years ago
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Cake day: July 4th, 2023

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  • I think probably because there’s no sensory input and I’m just there floating in the darkness with only my breathing and heartbeat. It’s not like the whole time I’m in the tank I’m tripping, but I have had some psychedelic adjacent experiences. Not so much the visual and auditory hallucinations, but rather the psychedelic thoughts. Pondering the nature of my existence, fleeting moments of feeling cosmic and eternal, that sorta thing.

    I wouldn’t recommend psychedelics to everyone but I’m glad I’ve dabbled. Those in a stable mental state would probably have a worthwhile experience eating some shrooms and sitting down in the woods.










  • Our repair functions stop doing their job well as part of senescence. Increasing the chance and speeding up the development of tumors.

    Those repair functions working better than normal is one of the hallmark signs of cancer, specifically telomerase being reactivated. Senescence is anti cancer, not pro cancer. You know those HeLa cells that are immortal? Cancer cells. Having a time limit or replication limit on cells through senescence is a great way of limiting tumors.

    The two barriers to proliferation—senescence and crisis/apoptosis—have been rationalized as crucial anticancer defenses that are hard-wired into our cells, being deployed to impede the outgrowth of clones of preneoplastic and frankly neoplastic cells. According to this thinking, most incipient neoplasias exhaust their endowment of replicative doublings and are stopped in their tracks by one or the other of these barriers. The eventual immortalization of rare variant cells that proceed to form tumors has been attributed to their ability to maintain telomeric DNA at lengths sufficient to avoid triggering senescence or apoptosis, achieved most commonly by upregulating expression of telomerase or, less frequently, via an alternative recombination-based telomere maintenance mechanism. Hence, telomere shortening has come to be viewed as a clocking device that determines the limited replicative potential of normal cells and thus one that must be overcome by cancer cells.

    https://www.cell.com/cell/fulltext/S0092-8674(11)00127-9




  • I don’t disagree, but I’m not going to do the fall back asleep thing in 9 minute intervals. I’ll just set a second alarm for 15-60 minutes later, or just forgo the second alarm entirely and pass in and out of consciousness for however long I want. I hate the sound of alarms, so hearing that every 9 minutes isn’t going to improve anything.

    I never hear anyone talking about how much they enjoy spamming snooze, only complaints. At least for me, quitting snooze buttons fairly early on seems to be a wise decision.