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You’ll have just as good of an experience on either Intel or AMD. Framework is releasing a new generation of intel models in August so if you want the most cutting edge model and can wait those are a good bet. But personally I’m very happy with my current gen AMD model’s performance and efficiency so I’ll be waiting a while before another upgrade. There really aren’t any major downsides for any of the current options though, just personal preference.
I use Graphene on my phone and DivestOS on my tablet