If you live alone that’s a lot, if you live with 2 or 3 other people that’s regular amount

As a rule of thumb the most energy is used by things that deal with heat, that is heaters and heat pumps/AC, so i’d focus on efficiency of these

he can larp as great leader in miami, along cubans

from what i understand, part of it is because methadone has a very long half life, which means that patients don’t bounce from rush to crash every day but instead taper down slowly. also because it touches other receptors than opioid receptors in a way that helps in this case

in my country it used to be like this for 50 years, you get flat rate per day, counted up to fractions of day, separately for accomodation and food + everything else. you only have to keep transportation tickets

behold, disruption

i don’t mean beta-oxidation, it’s just a series of separated normal reactions. i mean something like this: when first learning about ketones, you might learn about aldol condensation, which has enol as a nucleophile and another carbonyl as electrophile. at some other point you might learn about strecker reaction, which has iminium ion as electrophile and cyanide as nucleophile. but really, what you can do is mix and match, and you can pair enolizable ketone and iminium (mannich reaction) or carbonyl and cyanide (cyanohydrin formation) and then generalize, for example you don’t need strictly ketone for mannich, you can use any electron rich conjugated system like malonate or nitroalkane anion (henry reaction) or phenol or indole. to figure this out you need to study mechanisms. these last two are usually treated as variants of friedel-crafts reaction, but really categories like this are fake

and to get that right, you need to know how these reactive intermediates look like, how reactive they are, what influences their stability which means that ochem starts with discussion of carbocations, carboanions, radicals, their shapes and orbitals involved, hyperconjugation, solvent effects and the like. and then first reactions taught are sn1/sn2, because these showcase these fundamentals nicely, and from there, it’s about introduction of more compound classes

we only had synthons introduced during lecture at around 4th year, and only for ochem path, it’s not doing a lot at that point and imo would have much more impact right after ochem intro course

i always thought that the idea of synthons should be taught early on https://en.wikipedia.org/wiki/Synthon

i’d say it’s more important to learn mechanisms because this way you can notice these patterns of reactivity easier. at some point you’d only get new reactions that are really just pieces of other reactions you know put in a new way

there’s zero reason to make chart like this, it’s both barely comprehensible and touching surface level stuff only (where are palladium couplings for one)

is there something you don’t understand? it doesn’t fucking matter what russians claim to have tested, you as nato resident are protected by nato’s ability to evaporate moscow and moscow residents survival instinct, meaning that they won’t start shit if they want to remain not evaporated. it works in any number of ways between any number of nuclear states, and can’t be undone

nothing. safety of people in nato is guaranteed by a several of icbms somewhere in wyoming or in some submarine with putin’s name on them. self-preservation is a mighty powerful instinct, and it worked for entire cold war. will easily work for a couple of decades more

random sample of 1000 people is a decent one, they even included error bars:

The poll has a margin of error of plus or minus 3.1 percentage points at a 95 per cent confidence level.

These things are under high voltage, so no. And then there’s several kg of mercury inside

no, but they will also kill you (but not by magic)

really, happens to the best of us

the same way they did in 2021

it’s straight up still not good enough

right after fusion power goes commercial, which also will power it all

I don’t want to be remembered at all. If I’m being remembered it means I’m dead.

Yuri Orlow in Lord of War (2005)